Current advances on the therapeutic potential of scutellarin: an updated review

Author:

Xie YifeiORCID,Sun Guotong,Tao Yue,Zhang Wen,Yang Shiying,Zhang LiORCID,Lu Yang,Du Guanhua

Abstract

AbstractScutellarin is widely distributed in Scutellaria baicalensis, family Labiatae, and Calendula officinalis, family Asteraceae, and belongs to flavonoids. Scutellarin has a wide range of pharmacological activities, it is widely used in the treatment of cerebral infarction, angina pectoris, cerebral thrombosis, coronary heart disease, and other diseases. It is a natural product with great research and development prospects. In recent years, with in-depth research, researchers have found that wild scutellarin also has good therapeutic effects in anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, treatment of metabolic diseases, and protection of kidney. The cancer treatment involves glioma, breast cancer, lung cancer, renal cancer, colon cancer, and so on. In this paper, the sources, pharmacological effects, in vivo and in vitro models of scutellarin were summarized in recent years, and the current research status and future direction of scutellarin were analyzed. Graphical Abstract

Funder

National Science Foundation of China

the Key R&D Program of Shan Dong Province

Chinese Academy of Medical Sciences Initiative for Innovative Medicine

Chinese Pharmacopoeia Commission Drug Standard Promoting Fund

Jiangsu Provincial Agricultural Science and Technology Independent Innovation Fund

Special Fund for Scientific Innovation Strategy-Construction of High-level Academy of Agriculture Science

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

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