Oxygen radical formation during cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes at varying hydrogen ion concentrations

Author:

Ahmed S. Sohail,Napoli Kimberly L.,Strobel Henry W.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Clinical Biochemistry,Molecular Biology,General Medicine

Reference24 articles.

1. Jones MC, Whiting PH, Innes A, Propper DJ, Edward N, Catto GRD: Biochemical abnormalities in serum and urines from renal transplant recipients receiving cyclosporine. Transplant Proc 21: 1487?1489, 1989

2. Whiting PH, Simpson JG, Davidson RJL, Thomson AW: Pathological changes in rats receiving cyclosporin A at imrnunotherapeutic dosages for 7 weeks. Br J Exp Pathol 64: 437?444, 1983

3. Ahmed SS, Strobel HW, Napoli K, Grevel J: Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes. J Pharm and Exp Therap 265(3): 1047?1054

4. Maurer G: Metabolism of cyclosporine. Transplant Proc 17: 19?26, 1985

5. Berthault-Peres P, Bonfils C, Fabre G, Just S, Cano J-P, Maurel P: Metabolism of cyclosporin A. II. Implication of the macrolide antibiotic inducible cytochrome P-450 3c from rabbit liver microsomes. Drug Metab Dispos 15: 391?398, 1987

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