Maintenance Therapy in Diffuse Large B Cell Lymphoma and Mantle Cell Lymphoma

Author:

Till Brian G.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Oncology

Reference75 articles.

1. Maurer MJ, Ghesquieres H, Jais JP, et al. Event-free survival at 24 months is a robust end point for disease-related outcome in diffuse large B-cell lymphoma treated with Immunochemotherapy. J Clin Oncol. 2014;32:1066–73.

2. •• Le Gouill S, Thieblemont C, Oberic L, et al. Rituximab after autologous stem-cell transplantation in mantle-cell lymphoma. N Engl J Med. 2017;377:1250–60. This study demonstrated an overall and progression-free survival benefit for younger patients with MCL that received 3 years of maintenance rituximab therapy following intensive induction and ASCT, compared with no maintenance therapy. This study established maintenance rituximab as a standard of care for MCL after ASCT.

3. Delarue R, Haioun C, Ribrag V, Brice P, Delmer A, Tilly H, et al. CHOP and DHAP plus rituximab followed by autologous stem cell transplantation in mantle cell lymphoma: a phase 2 study from the Groupe d’Etude des Lymphomes de l’Adulte. Blood. 2013;121:48–53.

4. Geisler CH, Kolstad A, Laurell A, Andersen NS, Pedersen LB, Jerkeman M, et al. Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group. Blood. 2008;112:2687–93.

5. • Hermine O, Hoster E, Walewski J, et al. Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL Younger): a randomised, open-label, phase 3 trial of the European Mantle Cell Lymphoma Network. Lancet. 2016;388:565–75. This study demonstrated a benefit of intensive cytarabine containing induction for younger patients with previously untreated MCL.

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