Author:
Öhman Josefine,Sjölin Elias,Cundari Maurizio,Johansson Fredrik,Gilbert Mike,Boele Henk-Jan,Svensson Pär,Rasmussen Anders
Abstract
AbstractClimbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber responses through in-vivo intracellular Purkinje cell recordings in decerebrated ferrets. The results show that while nucleo-olivary stimulation decreased the probability of a response occurring at all, it did not reduce the number of EPSPs. The results suggest that nucleo-olivary stimulation does not influence the number of EPSPs in climbing fiber bursts.
Funder
Leverhulme Trust
Vetenskapsrådet
Kungliga Fysiografiska Sällskapet i Lund
Crafoordska Stiftelsen
Thorsten och Elsa Segerfalks Stiftelse
Åke Wiberg Stiftelse
Magnus Bergvalls Stiftelse
Lund University
Publisher
Springer Science and Business Media LLC