Influence of mesna and cysteine on the systemic toxicity and therapeutic efficacy of activated cyclophosphamide

Author:

Wagner T.,Zink M.,Schwieder G.

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine

Reference27 articles.

1. Araujo CE, Tessler J (1983) Treatment of ifosfamide-induced urothelial toxicity by oral administration of sodium 2-mercaptoethane sulphonate (mesna) to patients with inoperable lung cancer. Eur J Clin Oncol 19:195?201

2. Ball CR (1966) Estimation and identification of thiols in rat spleen after cysteine treatment: relevance to protection against nitrogen mustard. Biochem Pharmacol 15:319?324

3. Berrigan MJ, Marinello AJ, Pavelic Z, Williams CJ, Struck RF, Gurtoo HL (1982) Protective role of thiols in cyclophosphasmide induced urotoxicity and depression of hepatic drug metabolism. Cancer Res 42:3688?3695

4. Brade WP, Herdrich K, Varini M (1985) Ifosfamide-pharmacology, safety and therapeutic potential. Cancer Treat Rev 12:1?47

5. Brandt EL, Griffin AC (1951) Reduction of toxicity of nitrogen mustards by cysteine. Cancer 4:1030?1035

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1. Ambulatory administration of 5-day infusion ifosfamide + mesna: a pilot study in sarcoma patients;Cancer Chemotherapy and Pharmacology;2009-07-09

2. Urological implications of cyclophosphamide and ifosfamide;Scandinavian Journal of Urology and Nephrology;2008-01-01

3. Metabolic Models of Cytotoxicity;Handbook of Drug Metabolism;1999-03-29

4. N3-methyl-mafosfamide as a chemically stable, alternative prodrug of mafosfamide;Bioorganic & Medicinal Chemistry Letters;1998-07

5. Trofosfamide;Anti-Cancer Drugs;1997-06

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