A phase II trial of CI-921 in advanced malignancies

Author:

Sklarin Nancy T.,Wiernik Peter H.,Grove William R.,Benson Laura,Mittelman Abraham,Maroun Jean A.,Stewart James A.,Robert Francisco,Doroshow James H.,Rosen Peter J.,Jolivet Jacques,Ruckdeschel John C.,Robert Nicholas J.,Vèlez-Garcìa Enrique,Bergsagel Daniel E.,Panasci Lawrence C.,van der Merwe Aletta M.,Longueville Jacques J.,Leiby Jane,Kowal Charles D.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference9 articles.

1. Grove WR, Fortner CL, Wiernik PH: Review of amsacrine, an investigational antineoplastic agent. Clin Pharm 1:320?326, 1982

2. Grove WR, Delap LW, Grillo-Lopez AJ: CI-921: An analog of amsacrine with experimental activity against solid tumors. Invest New Drugs 4:113?118, 1986

3. Baguley BC, Denny WA, Atwell GJ, Finlay GJ, Rewcastle GW, Twigden SJ, Wilson WR: Synthesis, antitumor activity, and DNA binding properties of a new derivative of amsacrine, N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino) phenylamino]-4-acridinecarboxamide. Cancer Res 44:3245?3251, 1984

4. Robert F, Mignucci M, Grove WR, Javier J, Asmar S, GrilloLopez AJ: Phase I study of CI-921: Single dose schedule. Proc Am Soc Clin Oncol 6:26, 1987

5. Grove WR, Grillo-Lopez AJ, Robert F, Harvey V, Leiby J, Javier J, Hardy J, Grever M: Optimizing therapeutic potential of Phase I studies: coordination of three worldwide studies of CI-921. Proc Eur Cong Clin Oncol 4:287, 1987

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