Exploring potential anti-inflammatory effects of medicinal cannabis-Reference-Cited by-同舟云学术

Exploring potential anti-inflammatory effects of medicinal cannabis

Published:2023-10-14 Issue:11 Volume:31 Page:
ISSN:0941-4355
Container-title:Supportive Care in Cancer
language:en
Short-container-title:Support Care Cancer

Author:

Gurgenci Taylan,Kijanka Gregor,Greer Ristan,Huggett Georgie,Good Phillip,Moniruzzaman Md,Hardy Janet^ORCID

Abstract

Abstract Purpose Inflammation is thought to play a key role in malignant disease and may play a significant part in the expression of cancer-related symptoms. Cannabidiol (CBD) is a bioactive compound in cannabis and is reported to have significant anti-inflammatory properties. Method Serial C-reactive protein (CRP) levels were measured in all participants recruited to a randomised controlled trial of CBD versus placebo in patients with symptoms related to advanced cancer. A panel of inflammatory cytokines was measured over time in a subset of these patients. Results There was no difference between the two arms in the trajectory of CRP or cytokine levels from baseline to day 28. Conclusion We were unable to demonstrate an anti-inflammatory effect of CBD in cancer patients. Trial registration ANZCTR 26180001220257, registered 20/07/2018.

Funder

The University of Queensland

Publisher

Springer Science and Business Media LLC

Subject

Oncology

Link

https://link.springer.com/content/pdf/10.1007/s00520-023-08069-8.pdf

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