In-Vivo Degradation of DNA-Based Therapeutic BC 007 in Humans

Author:

Davideit Hanna,Becker Susanne,Müller Johannes,Becker Niels-Peter,Göttel Peter,Abay Ayşe,Sinn Angela,Grossmann Matthias,Mallek Markus,Haberland AnnekathrinORCID,Weisshoff Hardy

Funder

AiF support GmbH, ZIM

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference24 articles.

1. Mueller J, Haberland A, Becker N-P, Wenzel K, Wallukat G, Goettel P, et al. The DNA-based therapeutic agent bc 007 completely neutralizes agonistic autoantibodies directed against β1-adrenoceptors: results of a phase 1 trial. J Am Coll Cardiol. 2018;71:A645.

2. Shaw JP, Fishback JA, Cundy KC, Lee WA. A novel oligodeoxynucleotide inhibitor of thrombin I In vitro metabolic stability in plasma and serum. Pharm Res. 1995;12:1937–42.

3. Hwang TL, Shaka AJ. Water suppression that works. Excitation sculpting using arbitrary wave-forms and pulsed-field gradients [Internet]. J Mag Reson. Ser. A. 1995. https://ac.els-cdn.com/S1064185885710479/1-s2.0-S1064185885710479-main.pdf?_tid=spdf-8173958a-b5a5-4ca1-b01e-31a2506cc3a0&acdnat=1519745841_0f53ed3785ccd92c18e9cff873485a52 . Accessed 27 Feb 2018.

4. Laborlexikon: altersabhängige Normwerte für Aminosäuren im Serum ≫ Facharztwissen für alle! ≪ [Internet]. [cited 2018 Mar 29]. http://www.laborlexikon.de/Lexikon/Tabellen/03-Aminosaeuren_im_Serum.htm .

5. Lundin KE, Gissberg O, Smith CIE. Oligonucleotide therapies: the past and the present. Hum Gene Ther. 2015;26:475–85.

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