Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5-bis (trifluoromethyl)-(9Cl)) in rats-Reference-Cited by-同舟云学术

Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5-bis (trifluoromethyl)-(9Cl)) in rats

Published:2011-07-30 Issue:1 Volume:37 Page:45-56
ISSN:0378-7966
Container-title:European Journal of Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Eur J Drug Metab Pharmacokinet

Author:

Zhang Hong,Liu Quanhai,Fan Tingting,Fang Yu,Li Ying,Wang Guoping

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Link

http://link.springer.com/content/pdf/10.1007/s13318-011-0055-8.pdf

Reference12 articles.

1. Akita H, Doki Y, Miyata H, Hirao T, Yano M, Takachi K, Miyashiro I, Sasaki Y, Ishikawa O, Ohigashi H, Imaoka S (2006) Clinical significance of the second cycle response to cisplatin-based chemotherapy as preoperative treatment for esophageal squamous cell carcinoma. J Surg Oncol 93(5):401–409

2. Beumer JH, Beijnen JH, Schellens JH (2006) Mass balance studies, with a focus on anticancer drugs. Clin Pharmacokinet 45(1):33–58

3. Gao W, Johnston JS, Miller DD, Dalton JT (2006) Interspecies differences in pharmacokinetics and metabolism of s-3(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-n-(4-nitro-3-trifluoromethylphenyl)-propionamide: the role of n-acetyltransferase. Drug Metab Dispos 34(2):254–260

4. Krajka-Kuźniak V (2007) Induction of phase II enzymes as a strategy in the chemoprevention of cancer and other degenerative diseases. Postepy Hig Med Dosw 61:627–638

5. Lahoz A, Donato MT, Montero S, Castell JV, Gómez-Lechón MJ (2008) A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations. Rapid Commun Mass Spectrom 22(2):240–244