Abstract
Abstract
Purpose of the Review
Alcohol abuse causes a wide range of disorders that affect the nervous system. These include confusion, cerebellar ataxia, peripheral neuropathy, and cognitive impairment. Chronic and excessive alcohol consumption is the primary cause of peripheral neuropathy. It is worth noting that peripheral neuropathy has no reliable treatment due to the poor understanding of its pathology.
Recent Findings
Coasting is a major feature of alcoholic neuropathy, largely due to chronic alcohol abuse. Its major features are hyperalgesia, allodynia, and burning pain. Even though much research was done in this area, still we do not have a full understanding of the mechanism of alcoholic neuropathy. However, some theories have been proposed. These include direct or indirect effects of alcohol metabolites, impaired axonal transport, suppressed excitatory nerve pathway activity, or imbalance in neurotransmitters. Activation of spinal cord microglia, mGlu5 spinal cord receptors, and hypothalamic-pituitary-adrenal axis also seem to be implicated in the pathophysiology of this alcoholic neuropathy. The goal of treatment is to impede further damage to the peripheral nerves while also restoring their normal physiology. Alcohol abstinence, intake of balanced diets, and treatment with medications are suggested including benfotiamine, alpha-lipoic acid, acetyl-l-carnitine, vitamin E, methylcobalamin, myo-inositol, N-acetylcysteine, capsaicin, tricyclic antidepressants, or antiepileptic drugs.
Summary
This review focuses on the many pathways that play a role in the onset and development of alcohol-induced neuropathy, as well as present the possible treatment strategies of this disorder, providing insights into a further search of new treatment modalities.
Funder
Medical University of Lublin
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Cell Biology,Molecular Biology,Pathology and Forensic Medicine
Reference176 articles.
1. Grochowski C, Blicharska E, Baj J, Mierzwinska A, Brzozowska K, Forma A, et al. Serum iron, magnesium, copper, and manganese levels in alcoholism: a systematic review. Molecules. 2019;24(7):1361.
2. •• Edwards S, Vendruscolo LF, Gilpin NW, Wojnar M, Witkiewitz K. Alcohol and pain: a translational review of preclinical and clinical findings to inform future treatment sstrategies. Alcohol Clin Exp Res. 2020;44(2):368–83. This study provides a comprehensive review of both preclinical and clinical findings that are related to the alcohol abuse and the induction of chronic pain.
3. World Health Organization. Global status report on alcohol and health 2018. World Health Organization 2018; https://wwwwhoint/publications/i/item/global-status-report-on-alcohol-and-health-2018 Accessed 24 Jul 2020.
4. Zaridze D, Brennan P, Boreham J, Boroda A, Karpov R, Lazarev A, et al. Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths. Lancet. 2009;373:2201–14.
5. World Health Organization. Global status report on alcohol and health 2011. World Health Organization. 2011; https://wwwwhoint/substance_abuse/publications/alcohol_2011/en/ Accessed 34 Jul 2020.
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献