Mechanisms towards compensation of long-term haemopoietic injury in mice after 5 Gy irradiation: In vivo and in vitro enhancement of superoxide anion production by granulocytes-Reference-Cited by-同舟云学术

Mechanisms towards compensation of long-term haemopoietic injury in mice after 5 Gy irradiation: In vivo and in vitro enhancement of superoxide anion production by granulocytes

Published:1992-08-01 Issue:4 Volume:12 Page:281-292
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Gaitán Soledad¹,Cuenllas Elvira¹,Sancho Pilar¹,Bueren Juan A.²,Tejero Concepción¹

Affiliation:

1. Departamento Bioquímica y Biología Molecular IV. Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain

2. Unidad de Biología Molecular y Celular, CIEMAT, Madrid, Spain

Abstract

This paper analyzes the long-term (6 and 12 months) function of mouse granulocytes after total body irradiation with a single dose (5 Gy) of X-rays. Superoxide anion production has been investigated in granulocytes from peripheral blood, and also in those harvested from long term bone marrow cultures, with the aim of correlating the environmental damage induced by radiation with the functional properties of granulocytes. An in vivo and in vitro enhancement of superoxide anion production and protein levels in granulocytes from irradiated mice is described. The presence of some colony stimulating factor in the supernatant of cultures from irradiated mice could play an important role in the priming of granulocytes.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/12/4/281/468496/bsr0120281.pdf

Reference27 articles.

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1. Canine Long-Term Bone Marrow Culture Neutrophil Production and Functionality;Acta Haematologica;2004

2. Glucose metabolism in bone marrow cells and granulocytes of adult mice after X-ray (5 Gy) irradiation: relationship to cell functionality;British Journal of Haematology;1997-03

3. Long-term haemopoietic injury in mouse by 1 Gy X-rays at different postconceptional stages;International Journal of Radiation Biology;1997-01

4. Residual Haematopoietic Damage in Adult and 8 Day-old Mice Exposed to 7 Gy of X-rays;International Journal of Radiation Biology;1993-01