The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed KCa2 Activator and NaV Blocker, is a Potent Novel Anticonvulsant-Reference-Cited by-同舟云学术

The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed KCa2 Activator and NaV Blocker, is a Potent Novel Anticonvulsant

Published:2014-09-26 Issue:1 Volume:12 Page:234-249
ISSN:1933-7213
Container-title:Neurotherapeutics
language:en
Short-container-title:Neurotherapeutics

Author:

Coleman Nichole,Nguyen Hai M.,Cao Zhengyu,Brown Brandon M.,Jenkins David Paul,Zolkowska Dorota,Chen Yi-Je,Tanaka Brian S.,Goldin Alan L.,Rogawski Michael A.,Pessah Isaac N.,Wulff Heike

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Neurology (clinical),Pharmacology

Link

http://link.springer.com/content/pdf/10.1007/s13311-014-0305-y.pdf

Reference47 articles.

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3. Wickenden AD, Krajewski JL, London B, et al. N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol 2008;73:977-986.

4. Roeloffs R, Wickenden AD, Crean C, et al. In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. J Pharmacol Exp Ther 2008;326:818-828.

5. Dalby-Brown W, Jessen C, Hougaard C, et al. Characterization of a novel high-potency positive modulator of K(v)7 channels. Eur J Pharmacol 2013;709:52-63.

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