High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains

Author:

Schwabenland MariusORCID,Hasavci Dilara,Frase Sibylle,Wolf Katharina,Deigendesch NikolausORCID,Buescher Joerg M.,Mertz Kirsten D.,Ondruschka Benjamin,Altmeppen Hermann,Matschke Jakob,Glatzel Markus,Frank Stephan,Thimme Robert,Beck Juergen,Hosp Jonas A.,Blank Thomas,Bengsch Bertram,Prinz MarcoORCID

Abstract

AbstractThe underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119+P2RY12+CD68+Iba1+HLA-DR+CD11c+SCAMP2+ microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8+ parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.

Funder

Albert-Ludwigs-Universität Freiburg im Breisgau

Publisher

Springer Science and Business Media LLC

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