The impact of susceptibility correction on diffusion metrics in adolescents
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Published:2021-04-24
Issue:8
Volume:51
Page:1471-1480
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ISSN:0301-0449
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Container-title:Pediatric Radiology
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language:en
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Short-container-title:Pediatr Radiol
Author:
Lahti KatriORCID, Parkkola RiittaORCID, Jääsaari PäiviORCID, Haataja LeenaORCID, Saunavaara VirvaORCID, Ahtola Annarilla, Ekblad Mikael, Ekblad Satu, Ekholm Eeva, Grönroos Linda, Haataja Leena, Huhtala Mira, Jaakkola Jere, Joensuu Eveliina, Karukivi Max, Kero Pentti, Korja Riikka, Lahti Katri, Lapinleimu Helena, Lehtonen Liisa, Lehtonen Tuomo, Leppänen Marika, Lind Annika, Manninen Hanna, Koivisto Mari, Mattson Mira, Maunu Jonna, Munck Petriina, Määttänen Laura, Niemi Pekka, Nyman Anna, Palo Pertti, Parkkola Riitta, Ripatti Liisi, Rautava Päivi, Saarinen Katriina, Saarinen Tiina, Saunavaara Virva, Setänen Sirkku, Sillanpää Matti, Stolt Suvi, Tuomikoski-Koiranen Päivi, Tuovinen Timo, Uusitalo Karoliina, Väliaho Anniina, Ylijoki Milla,
Abstract
Abstract
Background
Diffusion tensor imaging is a widely used imaging method of brain white matter, but it is prone to imaging artifacts. The data corrections can affect the measured values.
Objective
To explore the impact of susceptibility correction on diffusion metrics.
Materials and methods
A cohort of 27 healthy adolescents (18 boys, 9 girls, mean age 12.7 years) underwent 3-T MRI, and we collected two diffusion data sets (anterior–posterior). The data were processed both with and without susceptibility artifact correction. We derived fractional anisotropy, mean diffusivity and histogram data of fiber length distribution from both the corrected and uncorrected data, which were collected from the corpus callosum, corticospinal tract and cingulum bilaterally.
Results
Fractional anisotropy and mean diffusivity values significantly differed when comparing the pathways in all measured tracts. The fractional anisotropy values were lower and the mean diffusivity values higher in the susceptibility-corrected data than in the uncorrected data. We found a significant difference in total tract length in the corpus callosum and the corticospinal tract.
Conclusion
This study indicates that susceptibility correction has a significant effect on measured fractional anisotropy, and on mean diffusivity values and tract lengths. To receive reliable and comparable results, the correction should be used systematically.
Funder
University of Turku (UTU) including Turku University Central Hospital
Publisher
Springer Science and Business Media LLC
Subject
Radiology, Nuclear Medicine and imaging,Pediatrics, Perinatology and Child Health
Reference47 articles.
1. Tamnes CK, Roalf DR, Goddings AL, Lebel C (2017) Diffusion MRI of white matter microstructure development in childhood and adolescence: methods, challenges and progress. Dev Cogn Neurosci 33:161–175 2. Lebel C, Gee M, Camicioli R et al (2012) Diffusion tensor imaging of white matter tract evolution over the lifespan. Neuroimage 60:340–352 3. Lebel C, Treit S, Beaulieu C (2017) A review of diffusion MRI of typical white matter development from early childhood to young adulthood. NMR Biomed 32:e3778 4. Albaugh MD, Ducharme S, Karama S et al (2017) Anxious/depressed symptoms are related to microstructural maturation of white matter in typically developing youths. Dev Psychopathol 29:751–758 5. Hagler DJ, Hatton SN, Cornejo MD et al (2019) Image processing and analysis methods for the adolescent brain cognitive development study. Neuroimage 202:116091
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