Mechanisms of Anthracycline Cardiotoxicity and Strategies to Decrease Cardiac Damage
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-010-0146-y.pdf
Reference50 articles.
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2. Steinherz LJ, Steinherz PG, Tan CT, et al.: Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA 1991, 266:1672–1677.
3. • Cardinale D, Colombo A, Lamantia G, et al.: Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol 2010, 55:213–220. In a prospective clinical trial, 201 patients with AIC were treated with enalapril and carvedilol promptly after diagnosis of LV ejection fraction of 45% or less. Complete recovery of the ejection fraction occurred in 85 patients (42%). The percentage of responders decreased when the time from chemotherapy to diagnosis of reduced ejection fraction was greater than 4 months.
4. • Lipshultz SE, Alvarez JA, Scully RE: Anthracycline associated cardiotoxicity in survivors of childhood cancer. Heart 2008, 94:525–533. A review of results from the Childhood Cancer Survivor Study (CCSS) discussing increased cumulative incidence of chronic health conditions 30 years after treatment. The review highlights proposed pathophysiology that occurs during late-onset cardiotoxicity after childhood exposure and recommendations for monitoring and treatment.
5. Shan K, Lincoff AM, Young JB: Anthracycline-induced cardiotoxicity. Ann Intern Med 1996, 125:47–58.
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