Neural Mechanisms of Angiotensin II–Salt Hypertension: Implications for Therapies Targeting Neural Control of the Splanchnic Circulation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-011-0188-9.pdf
Reference50 articles.
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2. • Symplicity HTN-2 Investigators: Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 2010, 376:1903–1909. This study demonstrated long-lasting decreases in arterial pressure in patients with drug-resistant hypertension following bilateral renal denervation by radiofrequency ablation. This new technology suggests that regional sympathetic ablation may be a new direction for the development of devices to treat hypertension
3. Smithwick RH. Splanchnicectomy for essential hypertension; results in 1, 266 cases. JAMA. 1953;152(16):1501–4.
4. Esler M. The sympathetic system and hypertension. Am J Hypertens. 2000;13:995–1055.
5. Esler M, Lambert E, Schlaich MP. Chronic activation of the sympathetic nervous system is the dominant contributor to systemic hypertension. J Appl Physiol. 2010;109(6):1996–8.
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