Hypertension Management and Microvascular Insulin Resistance in Diabetes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11906-010-0114-6.pdf
Reference50 articles.
1. •• Barrett E, Eggleston E, Inyard A, et al.: The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action. Diabetologia 2009, 52:752–764. This comprehensive review examined insulin’s microvascular actions and the three discrete steps by which insulin acts to enhance its own delivery to muscle and thus its metabolic actions: relaxation of resistance vessels to increase total blood flow, relaxation of precapillary arterioles to increase the microvascular exchange surface area, and the transendothelial transport of insulin.
2. Liu Z, Liu J, Jahn LA, et al.: Infusing lipid raises plasma free fatty acids and induces insulin resistance in muscle microvasculature. J Clin Endocrinol Metab 2009, 94:3543–3549.
3. Liu Z: Insulin at physiological concentrations increases microvascular perfusion in human myocardium. Am J Physiol Endocrinol Metab 2007, 293:E1250–E1255.
4. Clerk LH, Vincent MA, Jahn LA, et al.: Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes 2006, 55:1436–1442.
5. Kim JA, Montagnani M, Koh KK, et al.: Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006, 113:1888–1904.
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