Quality by design: understanding the formulation variables and optimization of metformin hydrochloride 750 mg sustained release tablet by Box

Quality by design: understanding the formulation variables and optimization of metformin hydrochloride 750 mg sustained release tablet by Box–Behnken design

Published:2012-08 Issue:4 Volume:42 Page:213-220
ISSN:2093-5552
Container-title:Journal of Pharmaceutical Investigation
language:en
Short-container-title:Journal of Pharmaceutical Investigation

Author:

Lee Young-Lae,Kim Min-Soo,Park Myung-Yong,Han Kun

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science

Link

http://link.springer.com/content/pdf/10.1007/s40005-012-0032-5.pdf

Reference22 articles.

1. Cha K-H, Lee N, Kim M-S, Kim J-S, Park HJ, Park J, Cho W, Hwang S-J (2010) Development and optimization of a novel sustained-release tablet formulation for bupropion hydrochloride using Box–Behnken design. J Pharm Invest 40:313–319

2. Costa P, Sousa Lobo JM (2001) Modelling and comparison of dissolution profiles. Eur J Pharm Sci 13:123–133

3. Defang O, Shufang N, Wei L, Hong G, Hui L, Weisan P (2005) In vitro and in vivo evaluation of two extended release preparations of combination metformin and glipizide. Drug Dev Ind Pharm 31:677–687

4. Duan JZ, Riviere K, Marroum P (2011) In vivo bioequivalence and in vitro similarity factor (f2) for dissolution profile comparisons of extended release formulations: how and when do they match? Pharm Res 28:1144–1156

5. Dunn CJ, Peters DH (1995) Metformin: a review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. Drugs 49:721–749

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