1. Radio Frequency Ablation is delivered by inserting a closed umbrella-like instrument under fluoroscopy that is opened once placed to deliver radiofrequency energy to the tumor mass heating the tissue to a temperature that will result in cell necrosis.
2. Lara PN, Jr, Higdon R, Lim N et al. Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment, J Clin Oncol, 2001; 19(6) (March):1728–1733.
3. Comis RL, Aldige CR, Stovall EL. et al. A Quantitative Survey of Public Attitudes Towards Cancer Clinical Trials, 2000, Coalition of National Cancer Cooperative Groups.
4. Foster C. The Ethics of Medical Research on Humans, Cambridge University Press, 2001.
5. Institutional Review Boards/Research Ethics Boards are the US/Canadian based committees charged with reviewing all clinical trials before being offered to patients.