Use of Interleukin-1 Blockers in Pericardial and Cardiovascular Diseases

Author:

Emmi Giacomo,Urban Maria Letizia,Imazio Massimo,Gattorno Marco,Maestroni Silvia,Lopalco Giuseppe,Cantarini Luca,Prisco Domenico,Brucato Antonio

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Reference68 articles.

1. • Szekely Y, Arbel Y. A review of interleukin-1 in heart disease: where do we stand today? Cardiol Ther. 2018; https://doi.org/10.1007/s40119-018-0104-3 . Relevant review focused on the role of IL-1 in heart diseases and potential therapeutic effects of anti-IL-1 treatments.

2. Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: back to the future. Immunity. 2013;39(6):1003–18. https://doi.org/10.1016/j.immuni.2013.11.010 .

3. • Cavalli G, Dinarello CA. Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies. Rheumatol Oxf Engl. 2015;54(12):2134–44. https://doi.org/10.1093/rheumatology/kev269 . Clinical review highlighting the role of interfering with IL-1 in cardiovascular diseases and type 2 diabetes, conditions that are frequently encountered as co-morbidities in patients with rheumatic diseases.

4. •• Brucato A, Imazio M, Gattorno M, Lazaros G, Maestroni S, Carraro M, et al. Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence: the AIRTRIP randomized clinical trial. JAMA. 2016;316(18):1906–12. https://doi.org/10.1001/jama.2016.15826 . First controlled, randomized trial to determine the efficacy of anakinra for colchicine-resistant and corticosteroid-dependent recurrent pericarditis.

5. •• Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, et al. Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med. 2017;377(12):1119–31. https://doi.org/10.1056/NEJMoa1707914 . First controlled randomized double-blind trial to evaluate the efficacy of canakinumab for patients with previous myocardial infarction and a high-sensitivity C-reactive protein.

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