D-optimal designs for Poisson regression with synergetic interaction effect

Abstract

AbstractWe characterize D-optimal designs in the two-dimensional Poisson regression model with synergetic interaction and provide an explicit proof. The proof is based on the idea of reparameterization of the design region in terms of contours of constant intensity. This approach leads to a substantial reduction in complexity as properties of the sensitivity can be treated along and across the contours separately. Furthermore, some extensions of this result to higher dimensions are presented.