Covalent Versus Non-covalent Enzyme Inhibition: Which Route Should We Take? A Justification of the Good and Bad from Molecular Modelling Perspective
Author:
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Biochemistry,Bioengineering,Analytical Chemistry
Link
http://link.springer.com/content/pdf/10.1007/s10930-020-09884-2.pdf
Reference47 articles.
1. Schwartz PA, Kuzmic P, Solowiej J et al (2014) Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance. Proc Natl Acad Sci USA 111(1):173–178
2. Pettinger J, Jones K, Cheeseman MD (2017) Lysine-targeting covalent inhibitors. Angew Chem Int Ed 56(48):15200–15209
3. Bauer RA (2015) Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies. Drug Discov Today 20(9):1061–1073
4. Adeniyi AA, Muthusamy R, Soliman MES (2016) New drug design with covalent modifiers. Expert Opin Drug Discov 11(1):79–90
5. Powers JC, Asgian JL, Ekici ÖD, James KE (2002) Irreversible inhibitors of serine, cysteine, and threonine proteases. Chem Rev 102(12):4639–4750
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