Understanding Environmental Contaminants’ Direct Effects on Non-alcoholic Fatty Liver Disease Progression

Author:

Armstrong Laura E.,Guo Grace L.

Publisher

Springer Science and Business Media LLC

Subject

Public Health, Environmental and Occupational Health,Health, Toxicology and Mutagenesis,Management, Monitoring, Policy and Law,Nature and Landscape Conservation

Reference51 articles.

1. • Al-Eryani L, Wahlang B, Falkner KC, Guardiola JJ, Clair HB, Prough RA, et al. Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents. Toxicol Pathol. 2015;43(4):482–97. https://doi.org/10.1177/0192623314549960 This review of the current literature provides evidence for the impact that environmental chemicals have on the development of steatosis. An emphasis is placed on the novel findings of fungicides and herbicides contributing to TAFLD, compared to insecticides.

2. Joshi-Barve S, Kirpich I, Cave MC, Marsano LS, McClain CJ. Alcoholic, nonalcoholic, and toxicant-associated steatohepatitis: mechanistic similarities and differences. Cell Mol Gastroenterol Hepatol. 2015;1(4):356–67. https://doi.org/10.1016/j.jcmgh.2015.05.006 .

3. • Estes C, Razavi H, Loomba R, Younossi Z, Sanyal AJ. Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease. Hepatology. 2018;67(1):123–33. https://doi.org/10.1002/hep.29466 This publication emphasizes the growing prevalence and the increasing burden of NAFLD, and therefore provides essential significance in the need for greater understanding of risk factors and mechanisms that contribute to the disease.

4. Wong RJ, Aguilar M, Cheung R, Perumpail RB, Harrison SA, Younossi ZM, et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology. 2015;148(3):547–55. https://doi.org/10.1053/j.gastro.2014.11.039 .

5. Noureddin M, Vipani A, Bresee C, Todo T, Kim IK, Alkhouri N, et al. NASH leading cause of liver transplant in women: updated analysis of indications for liver transplant and ethnic and gender variances. Am J Gastroenterol. 2018;113(11):1649–59. https://doi.org/10.1038/s41395-018-0088-6 .

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