Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study

Author:

Dickinson Laura,Amin Janaki,Else Laura,Boffito Marta,Egan Deirdre,Owen Andrew,Khoo Saye,Back David,Orrell Catherine,Clarke Amanda,Losso Marcelo,Phanuphak Praphan,Carey Dianne,Cooper David A.,Emery Sean,Puls Rebekah

Funder

Australian Government National Health and Medical Research Council

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology

Reference42 articles.

1. World Health Organisation. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach. 2013. http://www.who.int/hiv/pub/guidelines/arv2013/download/en/ . Accessed 12 Aug 2015.

2. Haas DW, Seekins D, Cooper R, Gallant JE, Tashima K, Hicks C, et al. A phase II, double-blind, placebo-controlled, dose ranging study to assess the antiretroviral activity and safety of efavirenz in combination with open-label zidovudine with lamivudine at 36 weeks [DMP 266-005; abstract no. 22334]. The XII International AIDS Conference; Geneva: 28 Jun–3 Jul 1998.

3. Puls R, Amin J, Losso M, Phanuphak P, Nwizu C, Orrell C, et al. Efficacy of 400 mg efavirenz versus standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial. Lancet. 2014;383(9927):1474–82.

4. ENCORE1 Study Group. Efficacy and safety of efavirenz 400 mg daily versus 600 mg daily: 96-week data from the randomised, double-blind, placebo-controlled, non-inferiority ENCORE1 study. Lancet Infect Dis. 2015;15(7):793–802.

5. Dickinson L, Amin J, Else L, Boffito M, Egan D, Owen A, et al. Pharmacokinetic and pharmacodynamic comparison of once daily efavirenz (400mg versus 600mg) in treatment-naive HIV-infected patients: results of the ENCORE1 study. Clin Pharmacol Ther. 2015;98(4):406–16.

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