Author:
Sawamura Megumi,Arai Toshiro,Kawasumi Koh
Abstract
AbstractThirteen dogs with intervertebral disk disease (IVDD) and 3 dogs with cervical disk herniation (CVDH) were examined to determine the effects of acupuncture on energy metabolism. Acupuncture points GV14, GV20-1, BL18, BL23, BL26, GB30, and ST36 were selected for IVDD, while GV14, GV20-1, GB20, and BL23 were selected for CVDH. All dogs except no.13 did not receive medication during acupuncture treatment. Acupuncture effects were evaluated based on the IVDD/CVDH evaluation scales in Oji 2015 and Tanaka and Nakayama 2015. Blood samples were taken before and 30 min after acupuncture treatment. Pyruvate and lactate concentrations, lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) activity, the MDH/LDH ratio (M/L ratio), and LDH isozyme electrophoretic patterns served as energy metabolism markers. In IVDD/CVDH dogs that showed improvements, plasma pyruvate concentrations significantly decreased, the M/L ratio increased, and the plasma LDH isozyme pattern changed from predominantly LDH5 to predominantly LDH1. These data suggest that local redox potential is improved and energy metabolism is increased in dogs with IVDD/CVDH after acupuncture treatment. Acupuncture treatments may activate the citric acid cycle and increase ATP production, followed by improvement of the disease. Future studies with a large sample size are needed to clarify this hypothesis.
Publisher
Springer Science and Business Media LLC
Subject
General Veterinary,General Medicine
Reference19 articles.
1. Bergmeyer HU, Bernet E (1974) Malate dehydrogenase UV-assay. In: Bergmeyer HU (ed.) Methods of enzymatic analysis, 2nd edn. vol 1. Academic Press, New York, pp 613–617
2. Czok R, Lamprecht W (1974) Pyruvate phosphoenolpyruvate and D-glycerate-2-phosphate. In: Bergmeyer HU (ed) Methods of enzymatic analysis, 2nd edn. vol 3. Academic Press, New York, pp 1446–1451
3. Fry TR, Johnson AL, Hungerford L,Toombs J (1991) Surgical treatment of cervical disc herniations in ambulatory dogs: ventral decompression versus fenestration, 111 cases (1980–1988). Prog Vet Neurol 2:165–173. https://eurekamag.com/research/002/236/002236744.php
4. Han HJ, Young H, Kim JY, Jang HY, Lee B, Choi SH, Jeong SW (2012) Clinical effect of additional electroacupuncture on thoracolumbar intervertebral disc herniation in 80 paraplegic dogs. Am J Chin Med 38(6):1015–1025. https://doi.org/10.1142/S0192415X10008433
5. Hirakawa Y, Kawasumi K, Lee P, Mori N, Yamamoto I, Terasawa F, Arai T (2012) Determination of oxidative energy metabolism and plasma LDH isoenzyme patterns of dolphins. Open Vet Sci J 6:30–36. https://doi.org/10.2174/1874318801206010030