High Prevalence of Cervical High-Risk Human Papillomavirus Harboring Atypical Genotypes in Human Immunodeficiency Virus -Infected and -Uninfected First-Generation Adult Immigrant Women Originating from Sub-Saharan Africa and Living in France
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Published:2020-08-20
Issue:2
Volume:23
Page:308-319
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ISSN:1557-1912
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Container-title:Journal of Immigrant and Minority Health
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language:en
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Short-container-title:J Immigrant Minority Health
Author:
Mboumba Bouassa Ralph-Sydney, Gubavu Camelia, Veyer David, Robin Leman, Gravier Anne, Hocqueloux Laurent, Prazuck Thierry, Péré Hélène, Bélec LaurentORCID, Gubavu C., Gravier A., Hocqueloux L., Prazuck T., Patey O., Bouchaud O., Traore L., Youssouf M.K., Bélec L., Mboumba Bouassa R.-S., Péré H., Veyer D., , ,
Abstract
AbstractHuman papillomavirus (HPV)-related cervical lesions in first-generation immigrant African women in France should reflect the epidemiology of high-risk (HR)-human papillomavirus (HPV) infection in sub-Saharan Africa. First-generation immigrant African women attending the Centre Hospitalier Régional of Orléans, France, were prospectively subjected to endocervical swabs for HPV DNA PCR and Pap smear. Fifty women (mean age, 41.7 years) living in France (mean stay, 10.7 years) were enrolled, including 26.0% of HIV-negative women from general population and 74.0% of women with known HIV infection. Cervical HPV prevalence was 68.0%, with 56.0% of HR-HPV. HR-HPV -68 and -58 were the predominant genotypes (20.0% and 14.0%, respectively). HR-HPV-16 and HR-HPV-18 were infrequently detected. HIV-infected women showed a trend to be more frequently infected by HPV than HIV-negative women (70.3% versus 61.5%). Most women (84.0%) showed normal cytology, while the remaining (16.0%) exhibited cervical abnormalities and were frequently HIV-infected (87.5%). These observations highlight the unsuspected high burden of cervical HR-HPV infections mostly associated with atypical genotypes, HIV infection and cervical abnormalities in first-generation immigrant African women living in France.
Funder
French National Agency for Research on AIDS and Viral Hepatitis, and the National Public Health Agency
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health,Epidemiology
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