Benefits of Bisphosphonate Therapy: Beyond the Skeleton

Author:

Billington Emma O.ORCID,Reid Ian R.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism

Reference76 articles.

1. • Lyles KW, Colón-Emeric CS, Magaziner JS, Adachi JD, Pieper CF, Mautalen C, et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med. 2007;357(18):1799–809. https://doi.org/10.1056/NEJMoa074941Large randomized controlled trial comparing zoledronate to placebo in hip fracture patients. A 28% reduction in mortality was observed in the zoledronate group.

2. • Reid IR, Horne AM, Mihov B, Stewart A, Garratt E, Wong S, et al. Fracture prevention with zoledronate in older women with osteopenia. N Engl J Med. 2018. https://doi.org/10.1056/NEJMoa1808082Primary analysis of a large clinical trial of zoledronate in postmenopausal women with low bone density; safety analyses demonstrate a signal towards lower mortality, cardiovascular disease, and cancer in zoledronate group.

3. • Reid IR, Horne AM, Mihov B, Stewart A, Garratt E, Bastin S, et al. Effects of zoledronate on cancer, cardiac events, and mortality in osteopenic older women. J Bone Miner Res. 2019. https://doi.org/10.1002/jbmr.3860Prespecified secondary analyses of a large clinical trial of zoledronate in postmenopausal women with low bone density, detailing the effects on mortality, cardiovascular disease, and cancer.

4. Bliuc D, Tran T, van Geel T, Adachi JD, Berger C, van den Bergh J, et al. Mortality risk reduction differs according to bisphosphonate class: a 15-year observational study. Osteoporos Int. 2019;30:817–28. https://doi.org/10.1007/s00198-018-4806-0.

5. Sing CW, Wong AY, Kiel DP, Cheung EY, Lam JK, Cheung TT, et al. Association of alendronate and risk of cardiovascular events in patients with hip fracture. J Bone Miner Res. 2018;33(8):1422–34. https://doi.org/10.1002/jbmr.3448.

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