Downregulation of miR-221-3p contributes to IL-1β-induced cartilage degradation by directly targeting the SDF1/CXCR4 signaling pathway-Reference-Cited by-同舟云学术

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Downregulation of miR-221-3p contributes to IL-1β-induced cartilage degradation by directly targeting the SDF1/CXCR4 signaling pathway

Published:2017-02-24 Issue:6 Volume:95 Page:615-627
ISSN:0946-2716
Container-title:Journal of Molecular Medicine
language:en
Short-container-title:J Mol Med

Author:

Zheng Xin,Zhao Feng-chao,Pang Yong,Li Dong-ya,Yao Sheng-cheng,Sun Shao-song,Guo Kai-jin

Funder

National Natural Science Foundation of China

the Key Program of Science and Technique Development Foundation in Jiangsu Province

Research project of Jiangsu Provincial Health Department

China Postdoctoral Science Foundation funded project

Social development project of Xuzhou Municipal Science and Technology Bureau

Publisher

Springer Science and Business Media LLC

Subject

Genetics(clinical),Drug Discovery,Molecular Medicine

Link

http://link.springer.com/article/10.1007/s00109-017-1516-6/fulltext.html

Reference29 articles.

1. Hunter DJ, Zhang YQ, Niu JB, Tu X, Amin S, Clancy M, Guermazi A, Grigorian M, Gale D, Felson DT (2006) The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis. Arthritis Rheum 54:795–801

2. Hunter DJ (2011) Pharmacologic therapy for osteoarthritis—the era of disease modification. Nat Rev Rheumatol 7:13–22

3. Loeser RF, Goldring SR, Scanzello CR, Goldring MB (2012) Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 64:1697–1707

4. Ji Q, Xu X, Zhang Q, Kang L, Xu Y, Zhang K, Li L, Liang Y, Hong T, Ye Q et al (2016) The IL-1β/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis. J Mol Med (Berl) 94:771–785

5. Barter MJ, Bui C, Young DA (2012) Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs. Osteoarthr Cartil 20:339–349

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