Hepatic and intestinal glucuronidation of mono(2-ethylhexyl) phthalate, an active metabolite of di(2-ethylhexyl) phthalate, in humans, dogs, rats, and mice: an in vitro analysis using microsomal fractions-Reference-Cited by-同舟云学术

Hepatic and intestinal glucuronidation of mono(2-ethylhexyl) phthalate, an active metabolite of di(2-ethylhexyl) phthalate, in humans, dogs, rats, and mice: an in vitro analysis using microsomal fractions

Published:2015-10-29 Issue:7 Volume:90 Page:1651-1657
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Hanioka Nobumitsu,Isobe Takashi,Kinashi Yu,Tanaka-Kagawa Toshiko,Jinno Hideto

Funder

Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00204-015-1619-1.pdf

Reference24 articles.

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2. Choi K, Joo H, Campbell JL Jr, Andersen ME, Clewell HJ 3rd (2013) In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat. Toxicol In Vitro 27:1451–1457

3. Fan J, Traore K, Li W, Amri H, Huang H, Wu C, Chen H, Zirkin B, Papadopoulos V (2010) Molecular mechanisms mediating the effect of mono-(2-ethylhexyl) phthalate on hormone-stimulated steroidogenesis in MA-10 mouse tumor Leydig cells. Endocrinology 151:3348–3362

4. Frederiksen H, Skakkebæk NE, Andersson AM (2007) Metabolism of phthalates in humans. Mol Nutr Food Res 51:899–911

5. Gupta RK, Singh JM, Leslie TC, Meachum S, Flaws JA, Yao HH (2010) Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro. Toxicol Appl Pharmacol 242:224–230

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