Hard-metal (WC–Co) particles trigger a signaling cascade involving p38 MAPK, HIF-1α, HMOX1, and p53 activation in human PBMC-Reference-Cited by-同舟云学术

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Hard-metal (WC–Co) particles trigger a signaling cascade involving p38 MAPK, HIF-1α, HMOX1, and p53 activation in human PBMC

Published:2012-09-28 Issue:2 Volume:87 Page:259-268
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Lombaert Noömi,Castrucci Eleonora,Decordier Ilse,Van Hummelen Paul,Kirsch-Volders Micheline,Cundari Enrico,Lison Dominique

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00204-012-0943-y.pdf

Reference46 articles.

1. Anard D, Kirsch Volders M, Elhajouji A, Belpaeme K, Lison D (1997) In vitro genotoxic effects of hard metal particles assessed by alkaline single cell gel and elution assays. Carcinogenesis 18:177–184

2. Brune B, Zhou J, von Knethen A (2003) Nitric oxide, oxidative stress, and apoptosis. Kidney Int Suppl 84:S22–S24

3. Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ Jr (1999) Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18:6845–6854

4. Chandel NS, Vander Heiden MG, Thompson CB, Schumacker PT (2000) Redox regulation of p53 during hypoxia. Oncogene 19:3840–3848

5. Chiacchiera F, Matrone A, Ferrari E, Ingravallo G, Lo Sasso G, Murzilli S, Petruzzelli M, Salvatore L, Moschetta A, Simone C (2009) p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription. Cell Death Differ 16:1203–1214

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