Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism-Reference-Cited by-同舟云学术

Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism

Published:2011-07-07 Issue:1 Volume:86 Page:87-95
ISSN:0340-5761
Container-title:Archives of Toxicology
language:en
Short-container-title:Arch Toxicol

Author:

Lin Jie,Schyschka Lilianna,Mühl-Benninghaus Ruben,Neumann Jan,Hao Liping,Nussler Natascha,Dooley Steven,Liu Liegang,Stöckle Ulrich,Nussler Andreas K.,Ehnert Sabrina

Publisher

Springer Science and Business Media LLC

Subject

Health, Toxicology and Mutagenesis,Toxicology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00204-011-0733-y.pdf

Reference22 articles.

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2. Chang-Liu CM, Woloschak GE (1997) Effect of passage number on cellular response to DNA-damaging agents: cell survival and gene expression. Cancer Lett 113:77–86

3. Donato MT, Jimenez N, Castell JV, Gomez-Lechon MJ (2004) Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes. Drug Metab Dispos 32:699–706

4. Donato MT, Lahoz A, Castell JV, Gomez-Lechon MJ (2008) Cell lines: a tool for in vitro drug metabolism studies. Curr Drug Metab 9:1–11

5. Ehnert S, Nussler AK, Lehmann A, Dooley S (2008) Blood monocyte-derived neohepatocytes as in vitro test system for drug metabolism. Drug Metab Dispos 36:1922–1929

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