Digital image analysis of Ki67 proliferation index in breast cancer using virtual dual staining on whole tissue sections: clinical validation and inter-platform agreement

Author:

Koopman Timco,Buikema Henk J.,Hollema Harry,de Bock Geertruida H.,van der Vegt BertORCID

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference25 articles.

1. American Cancer Society (2015) Global cancer facts & figures, 3rd edn. American Cancer Society, Atlanta

2. Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, van de Vijver MJ (2012) WHO classification of tumours of the breast, 4th edn. IARC Press, Lyon

3. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133(4):1710–1715

4. Denkert C, Budczies J, von Minckwitz G, Wienert S, Loibl S, Klauschen F (2015) Strategies for developing Ki67 as a useful biomarker in breast cancer. Breast 24:S67–S72

5. Dowsett M, Nielsen TO, A’Hern R et al (2011) International Ki67 in breast Cancer working group. Assessment of Ki67 in breast cancer: recommendations from the international Ki67 in breast Cancer working group. J Natl Cancer Inst 103:1656–1664

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