ROLE OF HS CRP AND LIPID ABNORMALITIES AS RISK FACTOR IN CORONARY ARTERY DISEASE

Abstract

BACKGROUND: In recent years, data suggesting that certain markers of inammation play a key role in the development and progression of atherosclerosis. hsCRP has shown promising results as a predictor of Coronary Artery Disease(CAD). OBJECTIVES: To evaluate the signicance of CRP as one of the most reliable markers in coronary artery disease and to study the role of lipid abnormalities as a risk factor in coronary artery disease. MATERIALS AND METHODS: Study was conducted at MedicalCollege, Kolkata.30 cases and 30 controls were studied. Angiographically proven cases of CAD aged between 40- 60 years of both sexes were included in the study as cases. Age and sex matched individuals without CAD weSre considered as cases. Patients with recent myocardial infarction, unstable angina (<6months).and with other inammatory conditions were excluded from the study. RESULTS: hsCRP was signicantly higher in CAD cases2.0±1.4 compared with controls0.8±0.7 and this was statistically signicant <0.001.Lipid parameters such as Total Cholesteol,Triglycerides and Low density lipoprotein were elevated in cases compared with controls and was found to be statistically signicant. Blood glucose parameters both in fasting and post-prandial conditions were found to be elevated in cases compared with controls. CONCLUSION: The study thus suggests that hsCRP level appears to be a dependable marker of CAD.Thus, hsCRP can be used as a sensitive predictor of CAD.