COMPARISON OF EFFICACY OF INDOMETHACIN AND TIZANIDINE IN EXPERIMENTAL MODEL OF ARTHRITIS IN ALBINO WISTAR RATS-Reference-Cited by-同舟云学术

COMPARISON OF EFFICACY OF INDOMETHACIN AND TIZANIDINE IN EXPERIMENTAL MODEL OF ARTHRITIS IN ALBINO WISTAR RATS

Published:2022-10-01 Issue: Volume: Page:47-48
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Mishra Ragini¹,John Abhay²,K. Tiwari Vikash³

Affiliation:

1. PhD Scholar, Department of Pharmacology, Index Medical College, Malwanchal University, Indore MP, India

2. Associate Professor, Department of Pharmacology, Index Medical College, Malwanchal University, Indore MP, India.

3. Assistant Professor, Department of Physiology, Autonomous state Medical College, Hardoi, UP, India

Abstract

Background: Rheumatoid arthritis is an autoimmune disease primarily affecting small peripheral join. It is characterised by joint inammation and pain. There were 3 groups with 6 albino wistar rats in each. Each group was i Methods: njected with CFA in one of hind paw on a day before (day 0) treatment with Indomethacin (3mg/Kg), Tizanidine (1mg/Kg), & Tizanidine (2mg/Kg). Each drug was given PO in their respective group. Joint size was measured on day 0, 3, 7, 14, and 21. Difference in joint size with day 0 was calculated. Difference in joint size on different Results: days of measurement was minimum for indomethacin & maximum for tizanidine (1mg/Kg). Difference of joint size for tizanidine (2mg/Kg) was in between two. Data was analysed using one way ANOVA. There was no signicant difference between the groups. Tizanidine has an Conclusions: anti-inammatory property in CFA induced rheumatoid arthritis experimental model. This property of tizanidine was more at dose of 2 mg/ Kg as compared to 1 mg/Kg. As tizanidine has gastro-protective effect so it can be a promising treatment along with NSAIDs.

Publisher

World Wide Journals

Subject

Clinical Biochemistry,Molecular Biology,Molecular Medicine,Biochemistry,Clinical Biochemistry,Molecular Biology,Pathology and Forensic Medicine,Cancer Research,Immunology and Microbiology (miscellaneous),General Medicine,Cell Biology,Toxicology,General Medicine,Pathology and Forensic Medicine,Cognitive Neuroscience,Neuroscience (miscellaneous),General Veterinary,General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine,Space and Planetary Science,Astronomy and Astrophysics,General Biochemistry, Genetics and Molecular Biology,General Neuroscience,Cell Biology

Reference16 articles.

1. Goljan EF. Musculoskeltal and soft tissue disorders. In: Goljan FE, eds. Rapid review of pathology. 4th ed. Philadelphia, PA: Saunders; 2014:641-43.

2. Wilkinson IB, Raine T, Kate Wiles K, Goodhart A, Hall C, Neill H. Oxford handbook of clinical medicine.10th ed. New York: Oxford University Press; 2017:538-63.

3. Hellmann DB, Imboden JB. Musculoskeletal & immunologic disorders. In Papadakis MA, McPhee SJ, Rabow MW, eds. Current medical diagnosis & treatment. 52nd ed. New York: McGraw-Hill; 2013:826-31.

4. Westfall TC, Macarthur H, Westfall DP. Adrenergic Agonists and Antagonists. In In: Brunton LB, Dandan RH, Knollmann BC, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill; 2018:607-29.

5. Tripathi KD. Essentialsof medical pharmacology. 8th ed. New Delhi: Jaypee brothers; 2019:384