TO ASSESS ROLE OF WORST PATTERN OF INVASION,DEPTH OF INVASION AND EXTRANODAL SPREAD IN PREDICTING RECURRENCE IN 1000 CASES OF SQUAMOUS CELL CARCINOMA IN ORAL CAVITY-SINGLE TERTIARY CANCER CENTER STUDY

Abstract

The incidence of oral squamous cell carcinoma (OSCC) remains high .Oral and oro-pharyngeal carcinomas are the sixth most common cancers in the world. Aim- The present study was conducted in a tertiary care cancer hospital in India to evaluate recurrence in squamous cell carcinoma of oral cavity. The present study was carried out in department of pathology at regional cancer tertiary centre from .Material And Methods- February 2011 to June 2021 .The cases were selected on basis of inclusion and exclusion criteria. The average age of the patients sufferingResults- from oral squamous cell carcinoma ( 48.8 years) with male predominance (M:F =9.7:1). Recurrence rate was 23.6%. Most common site of presentation was buccal mucosa. The most common grade in recurrent as well non recurrent cases was moderately differentiated . 388 patients out of 1000 had pathologically node positive disease. The recurrence rate among node positive was 27.5 % (107 out of 388). Non-cohesive pattern was more common in recurrent cases (55.92%) . Risk of recurrence was 82.62% with depth of invasion > 5 mm . Extranodal extension was seen in 34 cases (14.40%) . Perineural invasion , lymphovascular invasion and bone invasion was seen in 44.5% , 26.7% and 22.45% respectively . Out of total 236 recurrent cases, 3 year survival rate was 64.8%, 5 year survival rate was 34.7% and disease free survival rate was 81%. Conclusion- Squamous cell carcinoma of oral cavity has poor overall prognosis with high tendency to recur. Risk factors for recurrence are -lymphatic permeation, depth of invasion – 5 mm or more, poorly differentiated tumor, non- cohesive pattern of invasion .