“PREVALENCE OF H.PYLORI INFECTION IN PEPTIC ULCER DISEASE PATIENTS IN A TERTIARY CARE HOSPITAL, KURNOOL, ANDHRA PRADESH.”

Abstract

BACKGROUND: With the outstanding & revolutionary discovery of Helicobacter Pylori(H.Pylori) organism as a causative agent in Peptic Ulcer Disease (PUD), Gastric carcinoma and Malt Lymphoma, there has been a lot of interest generated about H.Pylori in modern times. The role of NonSteroidal Anti-Inammatory Drugs(NSAIDs) in the causation of Gastric Ulcer (GU) & Duodenal Ulcer (DU) is also an important point of study now-a-days. AIM & OBJECTIVES: To assess the prevalence of H.Pylori in patients of PUD diagnosed with Upper Gastro-Intestinal Endoscopic (UGIE) examination. MATERIALS & METHODS: Total 100 patients of the study underwent UGIE examination. Rapid Urease Test of gastric biopsy specimens of all patientswas done forthepresenceofH.Pylori. RESULTS:Out of 100PUDpatients, 74weremales&26were females.Out of 54H.Pylori associatedPUDpatients, 41(76%)weremales and 13(24%) were females. About 47% patients had GU, 43% had DU and 10% had both GU & DU. About 34(79%) DU patients were associated with H.Pylori infection. Out of 47 GU patients, 11(23%) are associated with NSAID usage, 7(15%) are associated with H.Pylori & other 53% had associated comorbidities like HTN, DM, CAD and CLD. Descriptive analysis in percentage was done by using MS Excel. CONCLUSION:Thendings ofthisstudy revealthatH.Pyloriinfection ismore common inmalesthan females.High prevalence ofH.Pyloriinfection isseeninDUpatients.NSAIDabusewas highinGUpatients.Thisstudyhighlightsthe signicanceofH.Pylori&NSAIDusage inPUDpatients.