REFERENCE CENTILE CHARTS OF PAPP-AAND FREE β-HCG IN INDIAN PREGNANT WOMEN.-Reference-Cited by-同舟云学术

REFERENCE CENTILE CHARTS OF PAPP-AAND FREE β-HCG IN INDIAN PREGNANT WOMEN.

Published:2021-04-01 Issue: Volume: Page:14-16
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Jindal Ankur¹,Prasad Anupa²,Polipalli Sunil Kumar³

Affiliation:

1. PhD student, Division of Genetics, Department of Pediatrics, MAMC & Associated Lok Nayak Hospital, New Delhi.

2. Associate Professor, Department of Biochemistry, Rajendra Institute of Medical Sciences, Ranchi.

3. Cytogeneticist, Division of Genetics, Department of Pediatrics, MAMC & Associated Lok Nayak Hospital, New Delhi.

Abstract

The combined rst-trimester screening (CFTS) for fetal aneuploidy involves a combination of maternal age, fetal nuchal translucency (NT), maternal serum pregnancy-associated plasma protein-A(PAPP-A) and free β-human chorionic gonadotropin (β-hCG) from 11+0 to 13+6 weeks of gestation [1]. International prescriptive standards for early fetal linear size and ultrasound dating of pregnancy in the rst trimester are available and used throughout the world. Ethnicity has an effect on the biochemical parameters of rst trimester screening. As there is a lack of reference chart for the women of Indian ethnicity, we aimed to nd out the level of PAPP-Aand free β-hCG for fetal crown rump length (CRL) of 40-84 mm in the rst trimester of pregnancy and construct the centile charts for both the parameters. Asignicant but weak correlation between the individual models of PAPP-A and β-hCG and CRL (P<0.001). In conclusion, the normal range of PAPP-A and free β-hCG depending on the gestation (CRL) was derived in this cohort study. This would act as a reference for our population and would be helpful in calculating the risk of an adverse maternal and fetal outcome.

Publisher

World Wide Journals

Reference10 articles.

1. Shiefa, S., Amargandhi, M., Bhupendra, J., Moulali, S., & Kristine, T. (2013). First Trimester Maternal Serum Screening Using Biochemical Markers PAPP-A and Free β-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian Journal of Clinical Biochemistry : IJCB, 28(1), 3–12. https://doi.org/10.1007/s12291-012-0269-9

2. Kapoor S, Gupta S, Kabra M. Prenatal screening: perspective for the pediatrician. Indian Pediatr. 2014 Dec;51(12):959-62. doi: 10.1007/s13312-014-0540-7. PMID: 25560151.

3. Papageorghiou AT, Kennedy SH, Salomon LJ, Ohuma EO, Cheikh Ismail L, Barros FC, Lambert A, Carvalho M, Jaffer YA, Bertino E, Gravett MG, Altman DG, Purwar M, Noble JA, Pang R, Victora CG, Bhutta ZA, Villar J; International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st). International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy. Ultrasound Obstet Gynecol. 2014 Dec;44(6):641-8. doi: 10.1002/uog.13448. Epub 2014 Nov 2. PMID: 25044000; PMCID: PMC4286014.

4. Spencer K, Heath V, El-Sheikhah A, Ong CY, Nicolaides KH. Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first trimester: A study of oriental, Asian and Afro-Caribbean populations. Prenat Diagn. 2005;25:365–9.

5. Chen M, Lam YH, Tang MH, Lee CP, Sin SY, Tang R, et al. The effect of ethnic origin on nuchal translucency at 10-14 weeks of gestation. Prenat Diagn. 2002;22:576–8