RETROSPECTIVE STUDY OF CLINICOPATHOLOGICAL PARAMETERS IN GASTRIC CARCINOMA.

Abstract

BACK GROUND: The incidence of gastric cancer is increasing worldwide, that presents with varied symptoms and signs. To diagnose gastric cancer in early stage we need to evaluate various clinical parameters and to grade the tumour we need to correlate with expression of P21 in tissue sample. METHODS: Clinical parameters like age, sex, symptoms & signs and tumour location of 50 patients were noted from the biopsy register and paraffin blocks with tumour of corresponding patients were evaluated for P21 expression by immunohistochemistry. CONCLUSION: In the present study, men were twice more commonly affected by gastric cancer than women. Most of the patients were aged above 50 years of age. P21 expression was found to be positive in most of the well differentiated grade and loss of P21 expression was noted in most of the poorly differentiated gastric adenocarcinoma.