Affiliation:
1. Department of Surgical Oncology. Thanjavur Medical College, Thanjavur, Tamilnadu,India.
Abstract
OBJECTIVES: To know the Perineural and lymphovascular space invasion in early operable breast cancer patients
since these are prognostic factors in patient's invasive carcinoma breast.
Methods: In this present study, Perineural and lymphovascular space invasion was studied pathologically in postmastectomy specimens in 134 patients.
RESULTS: In this study,6 (4.48%) patients had perineural invasion and 2 (1.49%) patients had only perineural invasion
without lymphovascular space invasion. 19(14.18%) patients had lymphovascular space invasion and 15 (11.2%)
patients had lymphovascular space invasion alone without perineural invasion. 4(3%) patients had both lympho
vascular space invasion alone and perineural invasion.
CONCLUSION: Lympho vascular space invasion, which impact the prognosis adversely, is present in 15% of the
patients with invasive carcinoma breast.
Reference8 articles.
1. Prevalence and significance of perineural invasion in invasive breast carcinoma. Soma Ghosh Karak et al. Conn Med. 2010 Jan. 74(1):17-21
2. Perineural invasion as a risk factor for loco regional recurrence of invasive breast cancer.Narayan P, Flynn J, Zhang Z, Gillespie EF, Mueller B, Xu AJ, Cuaron J, McCormick B, Khan AJ, Cahlon O, Powell SN, Wen H, Braunstein LZ. Narayan P, et al. Sci Rep. 2021 Jun 17;11(1):12781. doi: 10.1038/s41598-021-92343-4. Sci Rep. 2021. PMID: 34140615 Free PMC article
3. Issues relating to lymphovascular invasion in breast carcinoma. Hoda SA, Hoda RS, Merlin S, Shamonki J, Rivera M. Hoda SA, et al. Adv Anat Pathol. 2006 Nov;13(6):308-15. doi: 10.1097/01.pap.0000213048.69564.26. Adv Anat Pathol. 2006. PMID: 17075296 Review
4. Mohammed RA, Martin SG, Mahmmod AM, et al. Objective assessment of lymphatic and blood vascular invasion in lymph nodenegative breast carcinoma: findings from a large case series with long-term follow-up. J Pathol. 2011;223:358–65.
5. Hoda SA, Brogi E, Koerner FC, Rosen PP. Rosen's breast pathology. Philadelphia: Wolters Kluwer; 2014. [Google Scholar]