Affiliation:
1. Independent investigator
2. Independent investigator.
Abstract
The relationship between psoriasis and increased cancer risk is debated.The aim of this study was to evaluate if there is
an increase in the background risk of cancer in psoriasis patients compared with the general population.There was a
large heterogeneity in studies assessing cancer risk in psoriasis preventing from including all studies in meta-analysis.
This systematic literature review shows a small increased risk of some solid cancers in psoriasis,especially those linked
to alcohol drinking and cigarette smoking. A higher risk of non-melanoma skin cancers, especially squamous cell
carcinoma, is shown, mainly due to previous exposure to 8-methoxypsoralen-ultraviolet-A (PUVA), ciclosporin and
possibly methotrexate