IMAGING AND HISTOPATHOLOGICAL CORRELATION OF PROSTATIC LESIONS

Abstract

Background: To evaluate the role of a transrectal ultrasound (TRUS) guided biopsy and a color doppler test in the detection of prostate cancer in patients with increased serum prostate-specic antigen (PSA) levels and/or an abnormal digital rectal examination (DRE). A total of 30 cases, ranging in age from 50 to 80 yearsMethods: and showing increased serum PSA levels (>4ng/ml) and/or abnormal DRE, were enrolled and underwent TRUS evaluation followed by color Doppler owmetric studies. A TRUS-guided FNAC/biopsy was performed in all the cases. The ndings were conrmed histopathologically. Data were analyzed using the chi-square test. Histopathologically, a total of 11 casesResults: (36.66%) were malignant. On TRUS, irregular shape, heterogeneous echotexture loss of differentiation between the peripheral and internal zones, and capsular invasion were signicantly associated with malignancy. On owmetry, moderate vascularity and focal asymmetry were signicantly associated with malignancy. The combined use of TRUS and color Doppler owmetry was found to be 100% sensitive and 89.5% specic and had a positive predictive value (PPV) and a negative predictive value (NPV) of 84.6% and 100%, respectively. Trus with color doppler ultrasound plays an important role in the detectionConclusions: of prostatic malignancy with high sensitivity as well as specicity. The high negative predictive value, as observed in the present study could avoid unnecessary diagnostic invasive intervention.