THE RELATIONS OF DIABETES, TRACE ELEMENT, OXIDATIVE STRESS, AND HOMOCYSTEINE IN PATIENTS UNDERGONE OFF-PUMP CORONARY ARTERY BYPASS SURGERY

Abstract

Background: The main cause of atherosclerosis is the disruption of trace element biobalance and endothelial damage accompanied by increased oxidative stress. Methods: In this clinical prospective study, all diabetic patients were randomly selected according to the Euroscore II risk classication. Offpump coronary bypass surgery was performed in all cases. From the blood samples taken before and after the surgery, zinc and copper, malondialdehyde lipid peroxidase (MDA), superoxide dismutase (SOD), total oxidant/antioxidant capacity (TOS/TAC), nitric oxide (NO), HbA1c and homocysteine levels were analyzed. Results:Early postoperative processes were signicantly longer in the diabetic group. Trace elements did not change after surgery. TOS, NO, and SOD activities were signicantly increased in all groups compared with the control group. NO levels signicantly increased in the T1DM group compared with the control group. (p <0.05). There was a positive correlation between HbA1c and homocysteine, especially in T1DM (p <0.05). Conclusion: Zn/Cu and SOD levels were not affected by the operation in patients from the same risk group, and the hospital stay was longer in the diabetic group. NO, and MDA levels increased after surgery due to inammatory stress, but homocysteine levels did not change except in cases requiring a long hospital stay.