INFLUENCE OF HARVESTING SITES ON THE ANTIHYPERTENSIF EFFECTS OF ESSENTIAL OILS OF LIPPIA MULTIFLORA MOLDENKE (VERBENACEAE) IN BENIN-Reference-Cited by-同舟云学术

INFLUENCE OF HARVESTING SITES ON THE ANTIHYPERTENSIF EFFECTS OF ESSENTIAL OILS OF LIPPIA MULTIFLORA MOLDENKE (VERBENACEAE) IN BENIN

Published:2021-07-01 Issue: Volume: Page:44-47
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Gandonou Clément Dossa¹,Denis Tokoudagba Jean-Marie Kossi²,Houehoume Hypolite Ganse³,Fagbohoun Louis⁴,BabaMoussa Lamine Saïd⁵,Gbenou Joachim⁶,Ahissou Et Hyacinthe⁷

Affiliation:

1. Laboratoire d'Enzymologie et de Biochimie des Protéines, Faculté des Sciences et Techniques/Universitéd'Abomey-Calavi,01BP:188,Cotonou,Bénin.

2. Laboratoire de Chimie Pharmaceutique Organique, Ecole de pharmacie, Faculté des Sciences de la santé / Université d'Abomey-Calavi / Campus du champ de foire, 01 BP: 188, Cotonou, Bénin.

3. Laboratoire de Chimie Physique, Faculté des Sciences et Techniques /Université d'Abomey-Calavi, 01BP: 188, Cotonou, Bénin.

4. Laboratoire de chimie /Equipe de Recherche Appliquée aux Substances Artistique et Cultuo-Bioactive de l’Ecole Normale Supérieure Natitingou / Université Nationale des Sciences Technologies, Ingénierie et Mathématique du Bénin. BP: 72 Natitingou

5. Laboratoire de Biologie et de Typage Moléculaire en Microbiologie / Département de Biochimie et de Biologie cellulaire / Faculté des Sciences et Technique / Université d’Abomey-calavi / 05BP1604 Cotonou, Bénin.

6. Laboratoire de Pharmacognosie et des Huiles essentielles, Faculté des Sciences de Santé et Technologique / Université d’Abomey-Calavi / ISBA champ de Foire, 01BP : 918 Cotonou, Bénin.

7. Laboratoire d'Enzymologie et de Biochimie des Protéines, Faculté des Sciences et Techniques / Université d'Abomey-Calavi, 01BP: 188, Cotonou, Bénin

Abstract

A comparative study of the major compounds was carried out despite the great diversity of the constituents characteristic of the essential oil of Lippia multiflora. It was interested to note the imprint that makes each locality with the chemical characters of the gasoline. The variation in the chemical composition of essential oils, was depended on many factors such as the method used, the parts of the plant used, the products and reagents used in the extraction, the environment, the genotype of the plant, the geographic origin, harvest period of the plant, degree of drying, drying conditions, temperature and drying time and the presence of pests, viruses and weeds. The effects of essential oils of Lippia multiflora were evaluated in Wistar rats on arterial pressure (BP) and on heart rate (HR). Administration of L-NAME was caused a signicant increase in SBP in rats from 142.4 mmHg (D0) to 172.4 mmHg (D8) and from 122.8 mmHg (D0) to 138.6 mmHg (D8) respectively for the positive control batch and the batch subsequently treated with essential oil. Administration of the essential oil from D8 to D29 was caused a signicant decrease in the SBPof the rats from 140 mmHg (D8) to 122.4 mmHg (D29). This decrease was markedly lower than that of the untreated rats which is 150.5 mmHg (D29). The administration of L-NAME was caused a signicant increase in the DBPof the rats going from 93.8 mmHg (D0) to 137.5 mmHg (D8) and from 92.5 mmHg (D0) to 136.75 mmHg (D8) respectively for the positive control batch and the batch subsequently treated with essential oil.. The administration of the essential oil from D8 to D29 was caused a signicant decrease in the DBP of the rats going from 136.75 mmHg (D8) to 99.8 mmHg (D29) and nally the administration of L-NAME caused a signicant increase in the MAP of the rats going from 109.25 mmHg (D0) to 159.75 mmHg (D8) and from 99.8 mmHg (D0) to 151.25 mmHg (D8) respectively for the positive control group and the batch then treated with the raw extract). Administration of the essential oil from D8 to D29 was caused a signicant decrease in the AMP of the rats, dropping from 151.25 mmHg (D8) to 114 mmHg (D29) (p <0.05). These effects could be justify the use of this plant in traditional medicine in the treatment of high blood pressure.

Publisher

World Wide Journals

Reference35 articles.

1. Ameyaw YA, growth regulator for the propagation of Lippia multiflora Moldenke, a herbal for the management of mild hypertension in Ghana. Journal Medecine Plants Research, 2009 ; 3(9) : 681-685.

2. Dorosz P. Guide pratique des médicaments, 17ème édition Maloine, 1997 ; pp 6-10.

3. Adjanahoun EJ, Ake-Assi L. Médecine traditionnelle et pharmacopée : Contribution aux études ethnobotaniques et floristiques au Togo. Rapport ACCT, Paris, 1987 ; 256p.

4. AKE-ASSI L. ‘‘Description des espèces compagnes de Lippia multiflora dans les localités de Kpacouabo (Bouaflé), Niangoro (Séguéla) et N’gbessou (Yamoussoukro)’’, Notes prises sur le terrain. Féticheurs et médecine traditionnelle du Congo (Brazzaville). Mémoires O.R.S.T.O.M, 2012 ; 36, 282p.

5. Pascual ME, Slowing K, Carretero E, Sanchez Mata D, Villar A. Lippia : traditional uses, chemistry and pharmacology, a review. Journal of Ethnopharmacology, 2001 ; 76 : 201-214