USUAL VALUES OF GLOMERULAR FILTRATION RATE BY THE CG, MDRD AND CKD-EPI METHODS IN A SENEGALESE ADULT POPULATION

Author:

Diedhiou F.1,Ndiaye A1,Cisse F1,Samba A1,Thiam S1,Soumah Iy1,Agossou Hhm1,Tounkara Ar1,Ba R1,Dia Fkt1,Coly Nf2,D Doupa3,Diatta A.4,Agne Fd1

Affiliation:

1. FMPO/UCAD Medical Biochemistry Laboratory

2. LBM Children's Hospital of Diamniadio

3. Saint-Louis health department

4. Ziguinchor health department

Abstract

The estimation of the glomerular ltration rate (GFR), whose formulas are usually based on serum creatinine, is a fundamental data in clinical nephrology. The concept of “reference” or usual values adopted by health professionals is essential because of the paucity of research on the usual values of GFR in black Africa. The Modication of Diet in Renal disease (MDRD) and Chronik Kidney disease-Epidemiology collaboration (CKDEpi) equations were determined in non-African populations. Usual values specic to the black African population by the evaluation of the formulas of Cockroft and Gault (CG), MDRD and CKD-Epi must be rigorous and are the subject of this study. The GFR was determined using the CG, MDRD and CKD-Epi formulas in a sample of 233 presumed healthy Senegalese adults (118 men, 115 women). SPSS and Excel 2016 software were used for statistical analysis. A value of P<0.05 was considered statistically signicant. The determination of the GFR by the Cockcroft method overestimates the CKD values by 10.24 (9.82 - 14.53) with p=0.001 and that of the MDRD by 7.47 (5.91 - 9.03) the CKD values with p=0.001. For a GFR measurement uncertainty of +/- 10%, the CG and CKD formulas cannot be superimposed with a low correlation coefcient r = 0.52 and a coefcient of determination R² = 0.28; whereas those of MDRD and CKD-Epi are on the other hand superimposable with r = 0.79 and R² = 0.63. Thus, the CKD-Epi formula should be preferred for determining the usual value of GFR in a healthy person.

Publisher

World Wide Journals

Subject

Insect Science,Ecology, Evolution, Behavior and Systematics,Infectious Diseases,Immunology and Allergy,Medicine (miscellaneous),Epidemiology,Molecular Biology,Biochemistry,Infectious Diseases,Pulmonary and Respiratory Medicine,Aerospace Engineering,Mechanical Engineering,Energy Engineering and Power Technology,Aerospace Engineering,Computer Networks and Communications,Software,Electrical and Electronic Engineering,Communication,Artificial Intelligence,Information Systems,Control and Systems Engineering,Software,Urban Studies,Sociology and Political Science,Development

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