PHARMACOLOGICAL EVALUATION OF 2-PYRAZOLINE DERIVATIVES AS ANTI- INFLAMMATORY AGENTS

Abstract

Pyrazolines are prominent nitrogen-containing heterocyclic compounds and many pyrazoline derivatives have found their clinical application as NSAIDs. Side effects caused by selective NSAIDs always create a need for further investigation and studies of some newer anti-inammatory agents for various clinical conditions. Out of the studied compounds, 1-(3-(2-(1H-indol-3-yl)vinyl)-5-(1H-indol-3-yl)-4,5-dihydro-1H-pyrazol-1- yl)ethan-1-one was observed to have signicant anti-inammatory activity which can be benecial after further investigation and derivatization.