A COMPARATIVE STUDY OF TADALAFIL & TAMSULOSIN COMBINATION THERAPY VERSUS ALFUZOSIN MONOTHERAPY IN SEXUALLY ACTIVE PATIENTS OF BENIGN PROSTATIC HYPERPLASIA.

Abstract

BACKGROUND: The patients, suffering from LUTS due to BPH are generally treated with tamsulosin or silodosin .It was found that maximum patients are suffering from sexual dysfunctions while treating with with those drugs. So in this study we want to observe and compare the tamsulosin and tadalal combination with alfuzosin monotherapy. These two regimens were chosen because, as per nding of various previous studies, these two regimens can prevent and as well as treat the sexual adverse effects related to bph and tamsulosin/ silodosin monotherapy MATERIALAND METHODS: In this study 38 patients were given Tamsulosin (0.4mg) & Tadalal (5mg) xed dose combination therapy and 38 patients were given Alfuzosin (10mg). Symptom scores were assessed with the help of International Prostate Symptom Score (IPS Score), Quality of Lifestyle Score (QoL Score) and International index of erectile dysfunction score (IIEF 5). Uroowmetry was done to evaluate the change in Qmax. The evaluation of patients at each group was done at Day 1, 3 month, 6 months. RESULTS: In this study, patients of both regimens experienced a similar kind of signicant improvement of LUTS, maximum urinary ow(qmax) and better quality of life over time. In case of erectile dysfunction, patients of tamsulosin and tadalal combination experienced a rapid improvement, but after 6 months of therapy both groups experienced similar improvement in sexual well being. CONCLUSION: Alfuzosin is more cost effective and has similar efcacy in comparison to tamsulosin & tadalal combination for treating LUTS due to BPH in sexually active male patients.