EVALUATION OF SERUM CALPROTECTIN AS A PROGNOSTIC MARKER OF DISEASE SEVERITY IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AT A TERTIARY CARE HOSPITAL IN BIHAR-Reference-Cited by-同舟云学术

EVALUATION OF SERUM CALPROTECTIN AS A PROGNOSTIC MARKER OF DISEASE SEVERITY IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AT A TERTIARY CARE HOSPITAL IN BIHAR

Published:2021-12-01 Issue: Volume: Page:57-60
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Mishra Kripa Nath¹,Tripathy Subhrajyoti²,Thakur Manvendranath³,Raza Rakif⁴

Affiliation:

1. Professor, Dept. of Pediatrics, Darbhanga Medical College And Hospital DMCH, Bihar

2. 3 year Postgraduate, Dept. of Pediatrics, Darbhanga Medical College and Hospital DMCH, Bihar.

3. 3 year Postgraduate, Dept. of Pediatrics, Darbhanga Medical College and Hospital DMCH, Bihar

4. 2 year Postgraduate, Dept. of Pediatrics, Darbhanga Medical College and Hospital DMCH, Bihar

Abstract

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and one of the more common chronic illnesses during childhood. Calprotectin (S100A8/S100A9 protein) is known as a damage-associated molecular pattern (DAMP) protein and reects neutrophil activation during inammation. This study aims to evaluate the role of serum calprotectin as a marker to monitor the disease activity in children from Bihar, India with JIA. 107 children with JIA as per International League of Associations For Rheumatology (ILAR) criteria were recruited into the study, out of which 56 had active disease and 51 had inactive disease. Mean calprotectin value in children with active disease was found 2-fold higher than those with inactive disease. Also, calprotectin levels were analysed in 10 normal healthy children and it was observed that mean calprotectin value in children with active disease was 16-times higher than those who were normal healthy controls. Evidently, serum calprotectin levels were found to be a good marker of disease activity in children with JIA.

Publisher

World Wide Journals

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