COMPARISON OF THE EFFECTS OF FENTANYL VERSUS DEXMEDETOMIDINE ON AIRWAY REFLEXES AND HEMODYNAMIC RESPONSE TO TRACHEAL EXTUBATION FOLLOWING GENERAL ANESTHESIA

Abstract

Laryngospasm, bronchospasm, cough and tachycardia are physiological responses during anesthesia emergence and endotracheal extubation. Tracheal extubation should be performed while patient is deeply anesthetized to reduce airway reexes. Dexmedetomidine and fentanyl both have sedative and analgesic effect. The purpose of this study is to compare the effectiveness of dexmedetomidine or fentanyl on airway reexes and hemodynamic response to tracheal extubation following general anesthesia. 30 pati Method: ents of ASA I and II, aged between 18 to 55 year undergoing general anesthesia on elective basis were randomly divided in two groups.15 patients received 0.5 µg/kg dexmedetomidine while other patient received 1µg/kg fentanyl. Fifteen minutes before expected last surgical suture inhalational agent cut off and equal amount of solution of drug was given. All patients were extubated and all were monitored after extubation. The airway reexes to extubation, level of sedation and hemodynamic response were noticed. For nonparametric data Chi-square test and for para Statistical Analysis: Result: metric data t test was used. Total 30 patients were involved in the study. Dexmedetomidine was associated with increase quality of extubation compared with fentanyl. After extubation in fentanyl group heart rate was higher compared with dexmedetomidine group. In the dexmedetomidine group heart rate was not signicantly increase after extubation. When compared to fentanyl, participants in the dexmedetomidine group demonstrated more drowsiness during airway suctioning and extubation. Fentanyl group post-extubation patients were awake, whereas dexmedetomidine group patients were arousable. The nding of current study show that Single-dosage dexmedetomidine 0.5 μg/kg Conclusion: given 15 min before extubation created better response against airway reaction to laryngoscopy and effective in maintaining hemodynamic stability. This resulted in better tracheal extubation without prolonging recovery in comparison to fentanyl 1 µg/kg iv