Affiliation:
1. Department of Molecular and Cellular Engineering, Jacob Institute of Biotechnology and Bio- Engineering, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj- 211007, India
Abstract
Background: There is a pressing need for the development of some novel anti-cancer agent with potential effectivity and lesser side effects against
breast cancer, which is being the major cause of women death world wide. The need for this problem diverted the research towards evaluation of
anti-cancer efcacy of phytoconstituents from plants. The results from many in vitro and in vivo studies have suggested the efciency of many
compounds from different medicinal plants against the treatment and prevention of breast cancer The article is comprisedMain body of abstract:
of information dealing with major active phytoconstituents and their mechanism of action, against the major breast cancer cell lines, from Allium
sativum, Zingiber ofcinale, Catharanthus roseus, Curcuma longa, Panax ginseng, Nigella sativa, Camellia sinensis, Echinacea, Linum
usitatissimum, and Cimicifuga racemosa. The review presents the information of the in vivo and in vitro clinical studies conducted to evaluate the
action and efciency of the active compounds from these plants on breast cancer cell lines like, MCF-7 and MDA-MB-231. Short TheConclusion:
information from the article concludes that these medicnial carry some remarkable mechanism for combating infection and have shown a potential
anti-cancerous activity. The compounds, for full acceptance and administration, needs to be studied more in context with their bioavailability,
toxicity, safety and mode of administration that could bring out their maximum activity.