Preeklamptik Anne ve Bebeklerinde Asimetrik Dimetil Arjinin ve Oksidan/Antioksidan Düzeyi

Abstract

Aim: It is thought that asymmetric dimethyl arginine(ADMA) level is significantly higher in pregnant women with preeclampsia compared to healthy pregnant women, ADMA elevation develops before the clinical signs of preeclampsia, and ADMA plays a role in the pathogenesis of preeclampsia. In this study, it was aimed to investigate whether serum ADMA, total nitrite and nitrate (NOx), arginine and total antioxidant capacity (TAC) and levels in placenta samples taken from healthy and preeclamptic pregnant women and their babies are associated with preeclampsia, whether preeclampsia can be detected beforehand with these markers, and whether possible problems that may develop in the mother and baby can be prevented as a result. Material and Methods: 62 pregnant women and their babies who were followed up in Zonguldak Bülent Ecevit University obstetrics service are divided two groups; 31 preeclamptic pregnant and babies (Group I), formed Patient group; 31 pregnant and babies without preeclampsia (Group II), formed Control Group. Blood samples were obtained from mothers before birth, from the cord during birth, from babies in first 24 hours after birth and placenta samples were obtained from each pregnant to evaluate in the study. Age, weight, initial pregnancy state, pregnancy period, systolic and diastolic blood pressure levels of mothers with and without pre-eclampsia diagnosis, while birth weights, genders, problems and complications during treatment process, clinic and laboratory properties, prognosis, ADMA, arginine, NOx and TAC levels of babies were examined in this study. Results: There was no significant difference between two groups about antenatal factors that effect on prognosis. In the comparison of blood values, ADMA level of preeclamptic group was significantly higher (p